MILK THISTLE - Uses, Side Effects, and More

Medications changed by the liver (Glucuronidated Drugs) interacts with MILK THISTLE

The body breaks down some medications to get rid of them. The liver helps break down these medications. Taking milk thistle might affect how well the liver breaks down drugs. This might increase or decrease how well some of these medications work. Some of these medications changed by the liver include acetaminophen (Tylenol, others) and oxazepam (Serax), haloperidol (Haldol), lamotrigine (Lamictal), morphine (MS Contin, Roxanol), zidovudine (AZT, Retrovir), and others.

Tamoxifen (Nolvadex) interacts with MILK THISTLE

Milk thistle might increase how much tamoxifen is absorbed by the body. This might increase the effects and side effects of tamoxifen. Before taking milk thistle, talk to your healthcare provider if you are taking tamoxifen.

Medications for diabetes (Antidiabetes drugs) interacts with MILK THISTLE

Milk thistle can lower blood sugar levels. Taking milk thistle along with diabetes medications might cause your blood sugar to be too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed. Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Sirolimus (Rapamune) interacts with MILK THISTLE

Taking milk thistle might decrease how well the liver breaks down sirolimus. This might increase the effects and side effects of sirolimus. Before taking milk thistle, talk to your healthcare provider if you are taking sirolimus.

Raloxifene (Evista) interacts with MILK THISTLE

Taking milk thistle might decrease how well the body breaks down raloxifene in the intestines. This might increase the effects and side effects of raloxifene. Before taking milk thistle, talk to your healthcare provider if you are taking raloxifene.

Medications moved by pumps in cells (P-Glycoprotein Substrates) interacts with MILK THISTLE

Some medications are moved by pumps in cells. Milk thistle might make these pumps less active and increase how much of some medications get absorbed by the body. This might cause more side effects from some medications. Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, digoxin, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

Morphine interacts with MILK THISTLE

Milk thistle might affect levels of morphine in the blood. This might increase or decrease the effects of morphine. Before taking milk thistle, talk to your healthcare provider if you are taking morphine.

Warfarin (Coumadin) interacts with MILK THISTLE

Warfarin (Coumadin) is used to slow blood clotting. Taking milk thistle might make warfarin too effective, which could increase the risk of bleeding. Before taking milk thistle, talk to your healthcare provider if you are taking warfarin.

Estrogens interacts with MILK THISTLE

Milk thistle might increase how fast the body breaks down estrogen pills to get rid of them. Taking milk thistle along with estrogens might decrease the effectiveness of estrogen pills. Milk thistle contains a chemical called silymarin. Silymarin might be the part of milk thistle that helps the body break down estrogens. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with MILK THISTLE

Some medications are changed and broken down by the liver. Milk thistle might decrease how quickly the liver breaks down some medications. Taking milk thistle along with some medications that are broken down by the liver might increase the effects and side effects of these medications. Before taking milk thistle, talk to your healthcare provider if you take any medications that are changed by the liver. Some medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.

Medications used for lowering cholesterol (Statins) interacts with MILK THISTLE

Theoretically, milk thistle might change the levels of some medications used for lowering cholesterol (statins). This might decrease how well these medications work. Some medications used for lowering cholesterol include atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), and rosuvastatin (Crestor).

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with MILK THISTLE

Some medications are changed and broken down by the liver. Milk thistle might affect how quickly the liver breaks down some medications. Taking milk thistle along with some medications that are broken down by the liver might increase or decrease the effects of these medications. Before taking milk thistle, talk to your healthcare provider if you take any medications that are changed by the liver. Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), alprazolam (Xanax), amlodipine (Norvasc), clarithromycin (Biaxin), cyclosporine (Sandimmune), erythromycin, verapamil (Calan, Isoptin) and many others.

Indinavir (Crixivan) interacts with MILK THISTLE

Indinavir is a drug that is changed and broken down by the liver. Milk thistle might increase how quickly the liver breaks down some medications. But milk thistle does not seem to affect how quickly the body breaks down indinavir.

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