COMFREY - Uses, Side Effects, and More

Medications that can harm the liver (Hepatotoxic drugs) interacts with COMFREY

Comfrey might harm the liver. Taking comfrey along with medication that might also harm the liver can increase the risk of liver damage. Do not take comfrey if you are taking a medication that can harm the liver. Some medications that can harm the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others.

Medications that increase break down of other medications by the liver (Cytochrome P450 3A4 (CYP3A4) inducers) interacts with COMFREY

Comfrey is broken down by the liver. Some chemicals that form when the liver breaks down comfrey can be harmful. Medications that cause the liver to break down comfrey might increase the toxic effects of chemicals contained in comfrey. Some of these medicines include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

  • For back pain: About 4 grams of a specific ointment containing 35% comfrey root extract has been applied three times daily for 5 days. About 4 grams of another cream containing 35% comfrey plus 1.2% methyl nicotinate has also been applied three times daily for 5 days.
  • For osteoarthritis: About 2 grams of a specific ointment containing 35% comfrey root extract has been applied to the knee three times daily for 3 weeks. Also, about 3.5 grams of a specific cream containing comfrey extract, tannic acid, aloe vera gel, eucalyptus oil, and frankincense oil has been applied to the knee three times daily for 6-12 weeks.
  • For sprains: About 2 grams of a specific ointment containing 35% comfrey extract has been applied to ankle sprains four times daily for 8 days.

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