SkinMedica TNS Advanced Serum Review


Then, in 2008, the brand launched their TNS Essential Serum, which remained their most advanced product — until TNS Advanced Serum was released.

While these serums have similar names, TNS Advanced Serum is actually a completely different serum compared with TNS Essential Serum. In fact, the only similarity is that they both contain the patented growth factors.

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We’ll give you all the details on the key ingredients in this formula, as well as the research that supports (or doesn’t support) their use in skin care.

We’ll also share some SkinMedica TNS Advanced Serum reviews so that you can get an idea of what customers really think of this product.

Is SkinMedica TNS Advanced Serum Right For You?

Before we get into the details, here’s the TL;DR if you just want to know whether or not SkinMedica TNS Advanced Serum is right for you.

  • Key ingredients? Growth Factors, Peptides, Botanical and Marine Extracts
  • Skin type? All skin types; ideal for mature skin
  • Texture? Lightweight serum
  • Fragrance? No
  • Cruelty free? Unknown
  • Cost? $295 USD for 1 fl oz.

What Are The Key Ingredients in SkinMedica TNS Advanced Serum?

SkinMedica TNS Advanced Serum is said to improve the appearance of coarse wrinkles, fine lines, skin tone, and texture while also addressing sagging skin. According to the brand, you can see visible results in just 2 weeks and results continue to improve through 24 weeks of use.

The serum actually consists of two formulations that are dispensed via a dual chamber system; chamber 1 includes TNS-MR and chamber 2 consists of Renessensce (RSC) Advanced. Read on to learn exactly what’s in each of these formulations and how the ingredients will affect your skin.


TNS-MR includes human fibroblast conditioned media, the blend of patented growth factors that gave SkinMedica its reputation.

Growth factors are messenger proteins that are inherent in our bodies and are capable of stimulating cellular growth, proliferation, healing, and cellular differentiation. Growth factors play an important role in maintaining healthy skin, and topical application may help improve the appearance of fine lines, wrinkles, skin tone and texture.

Furthermore, TNS-MR contains two peptides: Progeline (Trifluoroacetyl Tripeptide-2) and Prolixir S20 (Dimer Tripeptide-43).

Progeline works by helping your skin to repair itself and therefore prevent signs of aging. You see, damaged skin cells need to constantly repair themselves in order for your skin to appear smooth and supple.Research has shown that a protein called progerin interrupts important tissue repair processes, which can lead to visible signs of skin aging. That’s why progerin is called the “skin- aging protein”. The proprietary ingredient Progeline has been developed to inhibit the synthesis of progerin by up to 22 percent.

Prolixir S20 is a patent-pending dimer tripeptide specifically designed to target the Ubiquitin-Proteasome (Ub-P) System and to help achieve successful aging through a sustained proteasome efficacy and less protein damage.

Renessensce (RSC) Advanced

The second chamber of SkinMedica TNS Advanced Serum contains Renessensce (RSC) Advanced, which is designed to support the results of the growth factor blend.

Specifically, Renessensce (RSC) Advanced contains a mixture of botanicals and marine extracts, such as chlorella, saccharide isomerate, hydrolyzed linseed extract, and grape stem cell extract.

Chlorella is a green microalgae that stimulates collagen synthesis and also has an anti-collagenase and an anti-elastase effect. Collagenase and elastase are enzymes that break down collagen and elastin, respectively. Since collagen and elastin are responsible for the strength and elasticity of skin, preventing the degradation of these proteins is important for maintaining a youthful complexion.

Saccharide Isomerate is a 100% plant-derived carbohydrate complex that functions as a water-binding agent, thereby improving hydration while also soothing skin.

Hydrolyzed linseed extract rejuvenates the skin by stimulating epidermal cell differentiation, increasing epidermis thickness, and increasing levels of glycosaminoglycans (GAGs) that are naturally found in the connective tissue. Ultimately, hydrolyzed linseed extract helps to improve the skin’s hydration and firmness, resulting in a more youthful complexion.

The final key ingredient we’d like to highlight is grape stem cell extract, a rich source of antioxidants like phenolic compounds, anthocyanins, and proanthocyanidins. While the stem cells themselves are not alive, the antioxidants in the extract help maintain adult skin cell production. Ultimately, this helps to reduce signs of aging, promoting smooth, firm, and hydrated skin.

How to Use SkinMedica TNS Advanced Serum?

Dispense SkinMedica TNS Advanced Serum on the back of your hand and blend together before applying to clean skin.

Where to Buy SkinMedica TNS Advanced Serum?

SkinMedica TNS Advanced Serum and other SkinMedica skin care products are sold on the brand’s website (, as well as through third-party online retailers such as,,, and others.

How Much is SkinMedica TNS Advanced Serum?

SkinMedica TNS Advanced Serum costs $295 USD for just 1 fl oz.

What is The SkinMedica Return Policy?

The SkinMedica return policy states, “We are committed to offering high-quality, scientifically proven products and want to ensure you are completely satisfied with your order. If you are not satisfied for any reason, we will accept returns within 30 days of your original purchase date.”

Is SkinMedica Cruelty-Free?

It is unknown if SkinMedica is cruelty-free as there isn’t any information available on the company website, Cruelty Free Kitty, PETA or Leaping Bunny.

SkinMedica TNS Advanced Serum Reviews

Unfortunately, this brand does not display SkinMedica reviews on their website, so we went over to to get an idea of what customers think of SkinMedica TNS Advanced Serum.

After more than 700 customer reviews, SkinMedica TNS Advanced Serum has earned an average rating of 4.7 out of 5 stars.

There are many 5-star reviews for SkinMedica TNS Advanced Serum from customers who love that it really helps to reduce lines and wrinkles while improving the overall look of skin.

For example, one review says, “This is a ‘one stop shop’ product. Worth the price! Makes a huge difference in skin tone and texture. And a little goes a long way. Highly recommend it.”

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And another 5-star review says, “I absolutely live by this product. I started using it a year ago and my skin is the best it’s ever been. I constantly get compliments on how my skin glows. It’s worth every single dollar!”

However, there are a handful of negative TNS Advanced Serum reviews, primarily from customers who experienced side effects like breakouts and rashes from this product.

For example, one review says, “I wish I could include a picture- my skin looked lovely with this for a few weeks and then all of a sudden a rash appeared all over my forehead- been to 3 dermatologists and they are said to was probably due to new skin care.”

Another 1-star review says, “I was so excited to purchase this whole line, which was very expensive. I read reviews and also was encouraged to purchase this line by the med spa that I use for Botox, etc. I have been using the line for one month and I am so disappointed. Do not think the product absorbs. My skin does not look great. I have a lot of breakouts on my cheeks which is weird and my skin looks dull. The product also pills or rolls off when applying makeup or trying to put on sunscreen……it is horrible. I called the med spa and they said to wait between applying layers, I did that with no improvement in the pilling. I went back to my original products this week and my skin already looks better. I am so sad.”

Our Verdict

Overall, we think that SkinMedica TNS Advanced Serum is formulated well, although we believe the serum is overpriced for what you get.

What Are Some Alternatives to SkinMedica TNS Advanced Serum?

If you’re looking for skin care products to address the signs of aging, one brand we recommend is Formulyst. Formulyst maximizes the use of powerful ingredients and minimizes the use of superficial ones, resulting in clinically advanced skin care solutions that help promote healthy, more youthful-looking skin.

One Formulyst product we recommend is the Ultimate Youth Concentrate. The formula combines plant cells with a concentrated combination of five unique peptides that can stimulate the production of Epidermal Growth Factors (EGF). EGF is a protein naturally found in cells called fibroblasts, which are responsible for producing collagen. It is thought that EGF signals to fibroblasts to produce more collagen, which leads to cell growth, proliferation, and wound healing.

Another brand that balances the power of plants with cutting edge science is Carrot & Stick. Not only is Carrot & Stick good for your skin, it is also good for the environment as the formulas skip harmful chemicals commonly found in skincare products.

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