Circadia Skin Care Review

Brand background

Circadia was founded by Dr. Peter T. Pugliese, MD, who has spent more than 40 years dedicated to the science of skin and aging. Dr. Pugliese believes that the integration of medicine, science, and nature is the basis for creating functional products to enhance skin health and longevity. Only ingredients that can be proven by science are used in the formulation of Circadia products. Michael Q. Pugliese, LE, grandson of Dr. Pugliese, is currently CEO of Circadia.

Key products and formulation

Another key product is the Circadia Vitamin C Reversal Serum, which is said to increase the firm look of skin and neutralize free radicals. The form of vitamin C found in this serum is magnesium ascorbyl phosphate (MAP). Compared to L- ascorbic acid (the biologically active form of vitamin C), MAP is more stable and can also penetrate the skin better. This form of vitamin C is also known to have a hydrating effect on the skin and decreases transepidermal water loss. According to the Indian Dermatology Online Journal, magnesium ascorbyl phosphate is also a free radical scavenger that is photoprotective and increases collagen production under laboratory test conditions. This serum also contains hyaluronic acid and Vitamin B5. Overall, the ingredients in the Circadia Vitamin C Reversal Serum work to brighten and firm your complexion.

The final key product from the Circadia line is the AquaPorin Hydrating Cream. Aquaporins are integral membrane proteins that serve as channels in the transfer of water, and in some cases, small solutes across the cell membrane. Circadia suggests that by stimulating certain aquaporins, skin health can be improved. For example, the ingredient Diffuporine (acetyl hexapeptide-37) is said to boost aquaporin-3, which promotes inner hydration mechanisms and water movement from the basal layer of epidermis and to the stratum corneum, rejuvenating the skin by improving barrier function, collagen I synthesis and cellular proliferation. Similarly, Aquasense (Piptadenia colubrina extract) increases Aquaporins-3, 9, and 10 to hydrate skin, increases fibronectin, and envelope proteins to improve corneocyte cohesion. In addition to these ingredients that stimulate aquaporins, this cream also contains natural oils for their emollient, regenerative and soothing properties.


Since Circadia treatments and retail products are sold exclusively through estheticians and physicians, the company does not feature reviews on their website. These products are sold on Amazon and have received an overall positive response from consumers. All three of the key Circadia products mentioned above have received ratings of 4 or more stars.

The Circadia Micro-Exfoliating Honey Cleanser reviews state that this product helps to control breakouts and promotes softer skin. Fortunately, none of the reviews for this cleanser mention any irritation or allergic reactions from the ingredient cocamidopropyl betaine.

Reviews for the Circadia Vitamin C Reversal Serum are also very positive, with users saying they notice results such as brighter and more firm skin. None of the reviews mention any burning or skin irritation, which is a possible side effect from other vitamin C products.

The Circadia AquaPorin Hydrating Cream reviews state that this product is an excellent moisturizer, especially for those with dry skin. It will help to keep the skin hydrated for many hours while giving the skin a youthful, dewy glow. One review mentioned that this cream helped to improve rosacea symptoms.

In sum, the Circadia line of skin care products by Dr. Pugliese contain unique and effective ingredients that have been clinically proven to address a variety of skin concerns caused by disrupted circadian rhythms.

What Are Alternatives to Circadia Skin Care

There’s no need to compromise when it comes to finding skincare that is effective and safe. Carrot & Stick takes a tough love approach to skincare, perfectly balancing the power of plants with cutting edge science. Not only is Carrot & Stick good for your skin, it is also good for the environment as the formulas skip harmful chemicals commonly found in skin care products.

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