Digestive Enzyme Supplements of 2021

Specialty: Ayurveda

Dr. Naveen Sharma is a renowned Ayurveda specialist with an experience of 10 years. He completed his Bachelor’s degree in Ayurveda, Medicine and Surgery(B. A. M. S) from Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka, in... more

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Digestive enzymes help break down food, so our body can absorb the nutrients. These nutrients are further broken into small molecules and released into the blood. However, sometimes, our body doesn’t produce enough digestive enzymes, and this may slow down digestion (1).

This can gradually lead to conditions like cystic fibrosis, chronic pancreatitis (inflammation of the pancreas), and pancreatic cancer (1). Fortunately, you can replenish these enzymes with the assistance of over-the-counter digestive enzyme supplements.

They are easily available in drugstores, health stores, or online. People who cannot produce enough digestive enzymes can use these supplements. In this article, we will be focusing on the 10 best digestive enzyme supplements, their benefits, and their side effects.

Note: Before consuming these supplements, it is recommended that you consult your doctor and test your digestive function.

1. Zenwise Health Daily Digestive Enzymes With Prebiotics & Probiotics

Zenwise Health’s Daily Digestive Enzymes contains a blend of plant-based enzymes that aid healthy digestion. These supplements ensure proper intake of vital nutrients that help in strengthening your digestive system. They are specially formulated to help with bloating, constipation, indigestion, and gas.

The prebiotic and probiotic blend supports digestion and enables your body to absorb all the nutrients from meals. It also contains a 10 plant-based enzyme blend with Amylase, Glucoamylase, Lipase, Protease, Invertase, Maltase, Cellulase, Bromelain, Lactase, and Papain. The turmeric and green papaya in them help reduce stomach bloating and any other discomfort.

Directions: Take one tablet immediately before every meal (three times a day).

2. Now Super Enzymes Tablets

This award-winning (Vitamin Retailer Magazine – Vity Awards) product is formulated with bromelain, ox bile, pancreatin, and papain. These are the best digestive enzymes as the ingredients break down fat, carbs, and proteins and optimize nutrient availability for a healthy digestive system.

Directions: Take one tablet with a meal.

3. Dr. Tobias Digestive Enzymes

Dr. Tobias Digestive Enzymes are formulated with 18 plant-based enzymes that help process difficult-to-digest foods like gluten, carbs, protein, sugar, fat, lactose, and fiber. They strengthen your digestive system and prevent digestive Problems such as post-meal gas.

Directions: Take one tablet with a meal.

4. Mav Nutrition Digestive Enzymes

Mav Nutrition Digestive is the best Enzyme that contains 3 essential types of probiotics for digestive health. Probiotics help in maintaining the healthy bacteria in the intestines for smooth digestive function. The best part about this product is that it does not contain artificial preservatives.

The formula contains protease, acidophilus, bromelain, lipase, and lactase. These constituents help in breaking down food. If you are experiencing diarrhea and indigestion and frequent occurrences of gas, these supplements will help purify your digestive system. They will help your system to digest proteins, fats, and carbohydrates without any discomfort. They relieve constipation and bloating.

Directions: Take one tablet, 20-30 minutes before or with the meal.

5. Dr. Matthew Digestive Enzymes

Dr.Matthew’s #1 Digestive Enzyme supplements are formulated using 19 plant-based enzymes, including amylase, bromelain, lipase, lactase, alpha-galactosidase, and pectinase.

This multi-enzyme blend is 6 times more potent for lactose digestion, 5 times more effective in digesting complex carbs, and 2 times more potent for proteins, fats, and gluten.

They reduce stomach bloating, gas, heartburn, diarrhea, indigestion, intestinal cramps, abdominal pain, belching, nausea, and fatigue. They help conditions like irritable bowel syndrome, constipation, acid reflux, and leaky gut. They help your body extract more nutrients from the food you eat so that you have more energy and vitality.

Directions: Take one tablet immediately before every meal.

6. Naturenetics DigestWise Powerful Digestive Enzymes

Naturenetics DigestWise Powerful Digestive Enzymes Supplements provide you with multiple enzymes like amylase, protease, pectinase, cellulase, alpha- galactosidase, amyloglucosidase, lipase, acid-stable protease, lactase, and hemicellulase that are carefully selected for their ability to work with a large pH range.

The broad spectrum of microbial-derived enzymes helps break down complex proteins, fats, sugars, carbohydrates, fiber, and dairy products. Due to this, you may feel less sluggish and more active. The enzymes are sourced from the USA, Denmark, Japan, Finland, and Belgium and are prepared in a state-of-the-art manufacturing facility in Oregon.

DigestWise is free of soy, dairy, gluten, wheat, sugar, yeast, and corn. These enzyme supplements ensure that you get all the potent nutrients from the food you eat. The supplements claim to give you great results within 90 days.

Directions: Take one tablet immediately before every meal.

7. Rainbow Light Advanced Enzyme System (Dietary Supplement)

Rainbow Light Advanced Enzyme System contains 10 plant-based enzymes like

  • Amylase to break down complex carbohydrates, sugars, and starches.
  • Lopase to break down complex fats found in nuts, oils, meats, and dairy products.
  • Protease to break down the proteins in eggs, cheese, and meat.
  • Invertase to break down sucrose.
  • Cellulase to break down the fiber in vegetables and grains.
  • Lactase to break down lactose.

These enzymes support a balanced digestive system. The formula contains enzyme- rich foods like green papaya, apple pectin, peppermint, fennel, and ginger to promote digestive comfort and reduce constipation, bloating, and gas. These supplements are the best enzymes for bloating

Directions: Take one tablet immediately before every meal.

9. Divine Bounty Digestive Enzymes

Divine Bounty Digestive Enzymes are designed to replenish and fortify your body’s enzyme levels to promote healthy digestion and 100% vital nutrients absorption. They are formulated with pre and probiotics enzymes for healthy digestion of fats, oils, proteins, carbohydrates, and dairy. With this, the lost energy from poor digestion is regained.

With regular use, these enzyme supplements support a healthy digestive system with bacterial balance. They contain galactosidase and beta-glucanase, which help break down beans, grains, and vegetables, and invertase and glucoamylase for digestion of sugars.

Directions: Take one tablet immediately before every meal.

10. Vimerson Health Digestive Enzymes

Vimerson Health Digestive Enzymes support overall gastrointestinal health. They contain a powerful blend of natural enzymes and probiotics for balancing the digestive system.

The formula includes protease to digest proteins and debris in the blood, bromelain to improve muscle health, papain, lipase, lactase to break down food and proteins into amino acids and amino blocks, and lactobacillus that supports healthy bowel movements.

Directions: Take one capsule 30 minutes before lunch, and one capsule 30 minutes before dinner.


These are the top 10 digestive enzyme supplements. The digestive system is also known as the ‘second brain.’ This because a healthy digestive system leads to a healthy body. Here are the benefits of digestive enzyme supplements. Take a look.

Benefits Of Digestive Enzyme Supplements

1. Help Digest Food Better

Digestive enzyme supplements are plant-based and microbe-derived enzymes that help break down proteins, carbohydrates, and lipids (3703/' target='_blank' rel='noopener noreferrer' >2). They keep your gastrointestinal system healthy and help in the management of multiple digestive disorders (3).

2. Boost Nutrient Absorption

Digestive enzyme supplements enhance nutrient absorption by breaking down proteins, fats, and carbohydrates from the food you eat. The nutrients are transported from the small intestine into the bloodstream to increase your energy levels.

The enzymes ensure that molecules like fats, carbs, and proteins are broken into smaller molecules so that they can get absorbed easily. This improves your immunity as well.

3. Reduce Bloating And Gas

Certain enzymes like alpha-galactosidase and cellulase break down complex carbohydrates like beans, vegetables, and grains. As these foods are difficult to digest, when the enzymes help break them down, conditions like gas, bloating and stomach pain are reduced.

Other sets of enzymes like lipase and lactase help break down fiber-rich veggies, dairy products, and legumes. These foods commonly cause gas and bloating. If you experience any discomfort after consuming these foods, digestive enzymes supplements may help.

4. Help Digest Dairy

Almost 68% of the world’s population is lactose intolerant (4). Many people lack the essential enzyme, lactase. Lactase helps digest lactose, a common type of sugar found in milk, ice cream, cheese, and other dairy products. Digestive enzyme supplements that contain lactase can help reduce symptoms of poor dairy digestion.

5. Reduce Gastrointestinal Disorders

According to a research project conducted on Functional Gastrointestinal Disorders at the Atlanta Center For Holistic And Integrative Medicine, 98 adults with Functional Gastrointestinal Disorder were asked to take probiotics and digestive enzymes for eight weeks. The results showed that the participants had improved gastrointestinal quality of life scores and underwent significant weight loss (5).

6. Reduce Acid Reflux

Acid reflux, also known as gastroesophageal reflux disease (GERD), is a digestive disorder that affects the lower esophageal sphincter. In other words, the stomach’s contents travel back into the esophagus, causing heartburn. Along with changes in lifestyle and diet, digestive enzyme supplements can help reverse the disorder. These supplements empty your stomach to reduce the reflux of stomach contents.

7. May Help Manage Irritable Bowel Disease

Irritable Bowel Syndrome is a disorder that affects the large intestine. It causes bloating gas and constipation. Since digestive enzyme supplements help break down complex carbs, proteins, and fats, they can help reduce the symptoms of IBS (Irritable Bowel Syndromes). These supplements include essential components like lactobacilli and probiotics that help with indigestion (6).

8. May Give You Clearer Skin

A healthy digestive system is connected to various functions of your body. That includes your skin too! If your body is not absorbing essential nutrients, the effect can be seen on your skin. If there is a lot of inflammation in your system, you may experience breakouts and acne.

Now that you are aware of the benefits, let’s look at things you need to know before consuming digestive enzyme supplements.

What You Need To Be Aware Of Before Taking Digestive Enzyme Supplements

Digestive enzyme supplements have a flip side. Find out what it is in the next section.

Are There Any Side Effects?


Since digestives enzyme supplements are sourced from plants, the side effects are negligible. But, in some cases, they can cause mild allergic reactions to a specific enzyme, resulting in continuous diarrhea, nausea, or stomach cramps.

Read the label thoroughly to check if you are allergic to any of the ingredients. If you are experiencing inflammation or heartburn, consult a doctor immediately.


If you are experiencing gas, bloating, and indigestion after every meal, these digestive enzyme supplements may work wonders. However, the symptoms differ from person to person. Therefore, before using these supplements, consult a doctor to avoid any complications. Although there are many benefits of these supplements, research shows limited results. Hence, exercise caution.

Let us know how these products worked for you by leaving a comment below.

Frequently Asked Questions

Do digestive enzyme supplements really work?

Yes. But, to get complete benefits, it is suggested that you use these supplements every day for a month.

Can digestive enzyme supplements help with weight loss?

It depends on your body type. However, healthy digestion leads to a healthy body. You do not have to worry about your weight as your body will receive all the essential nutrients at the right time.

How long does it take for digestive enzyme supplements to work?

Since these supplements do not need much time to be absorbed by your body, they work within 5 to 20 minutes. But it takes up to 30-40 days to regulate the natural digestion process.

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