Psoriasis Drug May Lower Heart Disease Risk

Psoriasis, a chronic inflammatory condition, is one of the most common skin disorders in the United States. It affects more than 100 million people worldwide.

The skin cells of people with psoriasis multiply faster than normal, which produces raised red bumps on the skin, often on the knees, scalp, and elbows.

Though psoriasis affects such a large proportion of adults, its causes are unclear, and it cannot currently be cured.

Over the years, a link has been found between psoriasis and an increased risk of cardiovascular disease. This relationship is particularly pronounced in individuals who have severe psoriasis.

Ustekinumab, psoriasis, and the heart

Dr. Gelfand adds, “Since ustekinumab blocks the specific pathways involved in both skin and cardiovascular inflammation, we wanted to test whether it can improve aortic vascular inflammation.”

Investigating aortic inflammation

Their study involved 43 participants with psoriasis, of whom 21 were assigned to the control group and 22 received ustekinumab.

The researchers were particularly interested in one measurement: aortic inflammation, which was measured using positron emission topography and computed tomography scans. The scans took place at the start of the study and after 12 weeks.

The results were relatively clear-cut. As expected, more than three quarters of the participants who took ustekinumab saw significant improvement in psoriasis symptoms.

The most interesting changes were measured in the heart: the participants in the control group saw a 12 percent increase in aortic inflammation, whereas members of the experimental group showed a decrease of 6.6 percent.

That means that, relative to individuals not taking the drug, ustekinumab was responsible for a 19 percent reduction in aortic inflammation.

Of course, the results are important for anyone with psoriasis, but the researchers see an even greater potential for this drug.

“This is the first placebo-controlled trial of a biologic drug to show a benefit in aortic inflammation, a key marker of cardiovascular disease. The effect is similar to what we would expect if we put the patient on a statin.”

Dr. Joel M. Gelfand

He adds, “This study represents promise that this treatment may reduce the risk of heart attack and stroke in the future. It’s an encouraging finding.”

Of course, this is just the start of the investigative journey; much more work needs to be done, involving many more participants. The next phase of trials is already in the pipeline.

Firstly, Dr. Gelfand wants to follow-up the participants in the current study to see whether the effect on aortic inflammation persists. It is important to understand whether the improvement continues, stagnates, or declines.

Now, 1 in 4 deaths in the U.S. are due to heart disease, so uncovering new potential interventions is encouraging news.

Read more on: psoriasis