New Compound Could Fight Off Aggressive Melanoma
Melanoma is a type of skin cancer that accounts for 1 percent of all skin cancer cases. Despite this small percentage, melanoma is responsible for a large number of skin cancer deaths.
According to the American Cancer Society, over 96,000 people in the United States will develop melanoma in 2019, and more than 7,000 will die as a result.
A mutation in a gene that scientists call NRAS causes one form of melanoma to be particularly aggressive. Normally, the NRAS gene encodes a protein of the same name that is mainly involved in regulating cell division.
However, NRAS is an oncogene, meaning that when it mutates, it has the ability to turn normal cells into cancerous cells. Melanoma with NRAS mutations accounts for 20â€“30 percent of all melanoma cases.
Prof. Cui explains the motivation for the research, saying, â€œThere are immunotherapies and targeted therapies that have shown huge improvements for patients with melanoma.
â€œHowever, for patients with NRAS mutations, they donâ€™t have very useful or very effective treatment strategies.â€
The role of the STK19 gene
In the search for such an effective treatment, the researchers examined the â€œchain reactionâ€ of genes â€” and their respective proteins â€” that trigger melanoma with NRAS mutations.
NRAS â€œacts like a genetic switchâ€ that is, in turn, turned on and off by other molecules. As Prof. Cui and team explain, until now researchers did not know precisely which proteins trigger NRAS.
However, after performing a series of experiments where they tested the effect of various proteins on NRAS activity, the scientists narrowed their search down to a protein called STK19.
They believe that STK19 switches NRAS â€œon,â€ which, in turn, activates other genes. Importantly, they could easily deactivate STK19, unlike NRAS.
STK19 inhibitor stops melanoma growth
Next, Prof. Cui and team plan to test their compound with human clinical trials. Until the results of such trials, hopefully, prove that the compound is effective in humans, we need more precisely targeted preventive measures against melanoma, caution the scientists.
â€œWe need more monitoring for early diagnosis and full-body examinations for problematic spots,â€ says Prof. Cui, â€œand more proactive strategies for patients [at the highest risk of developing melanoma] to prevent cancer progression and metastasis.â€
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