General Anesthesia Raises Dementia Risk Among Elderly Patients

Curated by Claudia Shannon / Research Scientist / ishonest

Elderly patients who are exposed to general anesthesia have a 35% higher risk of developing dementia, researchers from INSERM and University of Bordeaux, France, reported at Euroanaesthesia, the annual congress of the European Society of Anaesthesiology (ESA).

Dr Francois Sztark and team explained that POCD (post-operative cognitive dysfunction), a common complication of major surgery, could be linked to dementia several years after the procedure.

ishonest No.501 - Frizzy Hair

Recommended
No.501 - Frizzy Hair

Dr. Sztark said that experts believe there may be an association between POCD and subsequent dementia due to a common pathological mechanism through the amyloid ß peptide. According to a number of studies, some anesthetics might trigger inflammation of neural tissues leading to POCD, as well as Alzheimer’s disease precursors, including neurofibrillary tangles and ß-amyloid plaques. However, nobody was certain whether POCD might be a precursor to dementia.

Sztark and team analyzed dementia risk associated with anesthesia. They focused on patients aged 65+ years. The researchers looked at data from the Three-City study, which was designed to assess dementia and cognitive decline risk due to vascular risk factors. The study included data on 9,294 community-dwelling French seniors in Montpellier, Dijon and Bordeaux (between 1999 and 2001).

The seniors were interviewed at the start of the study, and then again 2, 4, 7 and 10 years later. Each assessment included a thorough cognitive evaluation with systematic screening for dementia. From the second follow up, 7,008 participants (without dementia) were asked each time whether they had a history of anesthesia – including general anesthesia or local/locoregional anesthesia since the previous follow up. The researchers adjusted the data to factor in possible confounders, such as comorbidities and socioeconomic status.

Sixty-two percent of the participants were female and their average age was 75 years.

Secret to my mothers youthful skin

Learn more

Below are some highlighted data from the study:

  • At the 2-year follow up 2,309 (33%) of participants had reported an anesthesia during the previous two years, 1,333 (19%) had general anesthesia (GA) and 948 (14%) had local/locoregional anesthesia (LRA)
  • Over the following 8 year period, 9% (632) of the participants developed dementia, 284 of them with probable Alzheimer’s disease (AD) and 120 with non-Alzheimer’s dementia
  • 37% of the participants with dementia had received anesthesia compared to 32% of the others
  • 22% of the dementia patients reported a GA versus 19% of those without dementia
  • After accounting for possible confounders, those with at least one GA had a 35% higher risk of developing dementia compared to the participants with recent (8-year) history of anesthesia

The researchers concluded:

“These results are in favour of an increased risk for dementia several years after general anaesthesia. Recognition of POCD is essential in the perioperative management of elderly patients. A long-term follow-up of these patients should be planned.”

Anesthesia exposure has not only been found to affect the brains of older people. Scientists from the Mayo Clinic reported in Mayo Clinic Proceedings (Feb 2013 issue) that children exposed to anesthesia many times have a higher risk of developing ADHD (attention-deficit/hyperactivity disorder).

Read more on: raises, dementia


What we do

We make skincare treatments and customize them for your skin-related problems, genetics, lifestyle, and environment.

How you benefit

You get total control over your skincare and the choice to change your skin. An impossible has just become possible.

How Custom Beauty Works

Desktop Mobile Graphic
Take the Quiz

Tell us about your skin, general health, lifestyle, environment, and all your skin goals. The quiz takes 4-8 minutes.

Outline of microscope
Create Your Treatment

Our algorithm creates a unique routine with a few customized products. The algorithm uses 50+ years of skincare research.

Outlines of Packaging
Divide and Rule

Every product is designed for one problem. Apply the product when the problem appears. Much like you treat flu or headache.

Product Values

A family sharing common values functions effortlessly and effectively. So do our products. All our products share these values.

Outline of bulb
Precise

Typical skincare routines confuse your skin with 20-50 ingredients. Our custom routines contain 1-8 ingredients, sending clear signals to your body to use the ingredients and recover faster.

Outline of Green Leaf
Concentrated

Our skin can use only active ingredients, also called actives. Most products contain up to 10% actives, whereas our products contain at least 90% actives. You get better value. Your skin avoids junk food.

Get Started

Never Used Before

Take the quiz below and discover a customized treatment for your unique skin-related problems, lifestyle, and environment.

Know Your Treatment

Every treatment has a unique 3-digit ID. You can find the ID on the product label. Search the ID on top right corner or click below.

Targeted Solutions

If a particular skin problem is bothering you, browse our products for your specific problem. You can customize your routine later.