Diabetes: Could Vitamin D Supplements Slow Progression?

According to the Centers for Disease Control and Prevention (CDC), type 2 diabetes and prediabetes now affect more than 100 million people in the United States.

Prediabetes describes a state wherein blood glucose levels are higher than normal, which increases the risk of developing diabetes.

In the U.S., an estimated 40% of adults are vitamin D deficient.

Some researchers have wondered if this might play a role in the development and progression of diabetes.

Early studies did find a link between low vitamin D levels and type 2 diabetes. For instance, a study from 2010 found that lower vitamin D levels were associated with reduced insulin sensitivity.

In type 2 diabetes, the body’s cells become less sensitive to insulin. Therefore, insulin cannot control blood sugar levels so effectively.

Looking deeper

Although a connection between vitamin D and diabetes was materializing, when scientists explored these findings with randomized controlled trials, the effects seemed to vanish.

One study that recruited people with vitamin D deficiency and diabetes concluded that vitamin D supplements did not improve insulin sensitivity. Another paper reached similar conclusions, and another concluded:

“Replenishment with a large dose of vitamin D-3 to [people] with [type 2 diabetes] and vitamin D deficiency did not change insulin sensitivity or insulin secretion.”

Other researchers came to similar conclusions. However, many of these early studies focused on people who had had diabetes for a long time, or who were not vitamin D deficient. Also, many of the studies ran for only a few weeks.

With this in mind, the latest study focused on vitamin D supplementation in people who had either received a diabetes diagnosis recently or were at risk of developing the condition. The trial ran for 6 months.

Diabetes and vitamin D

The scientists were mainly interested in measuring insulin sensitivity, but they also measured other factors — including insulin secretion, beta-cell function, and blood pressure.

The study — which the team conducted in Québec City, Canada — was a double- blind, placebo-controlled trial involving 96 participants. None of the recruits were taking diabetes medication, and none had taken medications that interact with vitamin D or vitamin D supplements in recent months.

Their results now appear in the European Journal of Endocrinology.

The researchers gave half of the participants 5,000 international units of vitamin D-3 every day for 6 months; this is around 5–10 times the recommended dose. They gave the other half of the participants a placebo that looked identical to the vitamin D-3 capsules.

Vitamin D is, in fact, a group of compounds. D-3, or cholecalciferol, is the version of vitamin D our bodies produce in the skin in response to sunlight.

At the end of the 6-month trial, the researchers assessed the participants once again. They concluded that:

“[H]igh-dose vitamin D supplementation for 6 months significantly improved peripheral insulin sensitivity […] and beta-cell function in individuals at high risk of diabetes or with newly diagnosed type 2 diabetes.”

They also showed that those with the poorest insulin sensitivity at baseline benefited the most from vitamin D supplementation. In participants who were at risk of diabetes but did not have impaired glucose sensitivity, vitamin D made no difference.

However, the researchers found no benefits in other measures, including fasting glucose, blood pressure, or body weight.

Why the different response?

As mentioned earlier, some trials were shorter or involved fewer participants. Another factor may be the way that the researchers assessed insulin sensitivity; in the recent study, they used a hyperinsulinemic euglycemic clamp. This is considered the gold standard measurement device.

In this study, only around half of the participants were vitamin D deficient when the study began. This is because, in some cases, there was a large gap between the initial screening and the start of the study.

This may have skewed the results. In fact, when the researchers conducted an analysis that only included those whose baseline vitamin D levels were normal, there was no difference in insulin sensitivity between the groups.

Overall, this paper — though not large enough to cast the winning dice — forms part of an ongoing exploration of the role of vitamin D in diabetes. We will have to wait for more studies to roll in before we can confirm or deny that vitamin D supplementation might help manage or reduce the risk of diabetes.

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