Could Vitamin D Help to Fight Diabetes?
Currently, there are around 30 million people in the United States living with type 2 diabetes, a lifelong condition that cannot yet be cured.
Obesity, one of the major risk factors, is steadily rising, meaning that the number of people with type 2 diabetes is likely to follow suit.
The condition is caused by faulty beta cells in the pancreas. These cells manufacture and release insulin, the hormone essential for controlling glucose levels in the blood.
If beta cells produce too little insulin, or none at all, glucose can accumulate in the blood at levels that are toxic to cells and tissues.
Vitamin D and diabetes
Vitamin D is often referred to as the sunshine vitamin because it is created in our skin in response to direct sunlight. Previous studies have found a connection between low vitamin D levels and a higher risk of diabetes, but the mechanisms involved have been challenging to unravel.
This is due, in part, to the wide-reaching physiological functions of vitamin D; for instance, vitamin D is involved in cell growth, bone maintenance, neuromuscular activity, and the immune system. Also, importantly for this study, it has been implicated in inflammation.
â€œWe know that diabetes is a disease caused by inflammation. In this study, we identified the vitamin D receptor as an important modulator of both inflammation and beta cell survival.â€
To reach these conclusions, the researchers created beta cells using embryonic stem cells. Then, they tested a battery of compounds to investigate what effects they had on them.
Boosting vitamin D in beta cells
The researchers found that a particular compound â€” called iBRD9 â€” boosted the activity of vitamin D receptors when they were bound to vitamin D molecules. This had a protective effect on the beta cells.
They demonstrated that, in a mouse model of diabetes, iBRD9 brought glucose levels back down into the normal range.
He continues, â€œItâ€™s been hard to protect beta cells with the vitamin alone. We now have some ideas about how we might be able to take advantage of this connection.â€
They identified a way in which vitamin D might protect beta cells. It seems to involve transcription, or how genes are decoded to produce proteins. The introduction of iBRD9 caused genes with a protective effect to be transcribed at higher rates, protecting the beta cells.
â€œBy using a screening system that we developed in the lab, weâ€™ve been able to identify an important piece of that puzzle that allows for super-activation of the vitamin D pathway.â€
While the findings have clear implications for scientists trying to design new drugs to treat diabetes, there are further-reaching possibilities.
Of course, before any drug can be used in humans, there are many essential hoops to be jumped through. Although there were no notable side effects in mice, only time will tell if it is safe for humans, too.