Humans are alive with trillions of microorganisms that live in and on the body and outnumber human cells tenfold.
Scientists are increasingly coming across examples of how these microbial cells and their genetic material â€“ known as the microbiome â€“ can promote or disrupt human health via their intimate relationship with the immune system.
The researchers behind the new study screened 10,000 colonies of commensal bacteria found on human skin to determine how many had antimicrobial properties. They also investigated how common they were on healthy and non-healthy human skin.
â€œWe discovered antimicrobial peptides produced by bacteria commonly found on healthy human skin. These novel antimicrobials have selective activity against pathogenic bacteria, but do not harm other commensal bacteria that have a beneficial effect to us.â€
Protective bacteria produce antibiotic against S. aureus
According to the National Eczema Association, 32 million people in the United States have eczema, including 18 million with moderate to severe eczema or atopic dermatitis â€“ which normally appears as a rash on arms, legs, and cheeks.
Previous research had shown that the disease-causing bacterium Staphylococcus aureus aggravates skin conditions like atopic dermatitis.
- Human skin provides around 19 square feet of diverse habitats for numerous species of bacteria, fungi, and viruses.
- Fetal skin is sterile, but it is soon colonized after birth.
- The gut is also home to over 1,000 known bacterial species.
Dr. Nakatsuji and colleagues found that other strains of Staphylococcus â€“ including Staphylococcus hominis and Staphylococcus epidermis â€“ residing on the skin of healthy people produce a previously unknown antimicrobial peptide that checks the growth of S. aureus.
When they colonized pigskin or mice with these protective strains of Staphylococcus, they found it reduced S. aureus replication.
â€œAfter isolating the good bacteria and growing it, we were able to transplant it back to people who were deficient in it and it had an immediate impact by reducing the amount of S. aureus on the skin,â€ he adds.
The team is already carrying out a phase II clinical trial to evaluate whether prolonged use of one of the most potent friendly bacteria offers long-term protection against S. aureus and alleviates atopic dermatitis.
Using a natural antibiotic produced in the skin is better than using a pharmaceutical drug because it does not kill protective bacteria, says Dr. Nakatsuji, adding that: â€œAntibiotic resistance is not likely to occur because the bacteria therapy is attacking pathogens by multiple different ways at once.â€
â€œWe now have a rational therapeutic approach for atopic dermatitis by using bacterial transplant technology. It appears that people with this disorder will need to have it reapplied because their body does not naturally promote the growth of these organisms. The good thing is this is easy to do because itâ€™s just a cream.â€
Prof. Richard Gallo
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