Can Skinceuticals A.G.E. Interrupter Really Interrupt Premature Aging?

Curated by Claudia Shannon / Research Scientist / ishonest

A.G.E. stands for advanced glycation end-products, abnormal structures that damage collagen and make your skin sag and age faster.

What causes them? Sugar. The more you eat, the more A.G.E.s your skin produces. Bummer!

ishonest No.222 - Fine Lines & Wrinkles

No.222 - Fine Lines & Wrinkles

I need my sugar fix every now and then, so I’m looking for other ways to undo, or at least stop, the damage A.G.E.s cause to my skin.

Enter Skinceuticals A.G.E. Interrupter. It features 30% proxylane™ to fight the wrinkles and sagging caused by the glycation process. Does it work?

What’s In Skinceuticals A.G.E. Interrupter?


Developed by L’Oreal (the owners of Skinceuticals), Proxylane is a sugarprotein hybrid derived from xylose, a natural sugar found in beechwood.

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According to L’Oreal, Pro-Xylane boosts the production of glycosaminoglycans (GAGs), a component of your natural skin’s barrier. The more GAGs your skin has, the more hydrated and firmer it is.


The base of this moisturiser is made up of silicones. It’s not as bad as you think. Silicones do a lot of good things in skincare:

  • Enhance texture: They allow the cream to glide on smoothly, without tugging or pulling.
  • Fill in fine lines and wrinkles: It’s a trick to make them look temporarily smaller.
  • Softens skin: It makes it feel silky soft to the touch.

They don’t even cause pimples: silicones have a particular molecular structure made up of larger molecules with wider spaces between each molecule. They create a barrier that keeps moisture in but still allows skin to perspire.

ishonest No.111 - Purge Impurities

No.111 - Purge Impurities

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Mousse-like, whipped texture. In the jar, it looks thicker than it is on the skin. It sinks in quickly, too.


White florals. I personally don’t like the smell of white florals, but I know many people who adore it. Just a matter of personal preference.

How To Use It

In the AM, in between serum and sunscreen. At night, it’s the last step of your skincare routine.

Performance & Personal Opinion

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Skinceuticals A.G.E. Interrupter isn’t the most moisturising cream I’ve tried. If you’ve got dry skin, this ain’t gonna cut it. You can pile it on and still your skin will demand more moisture than it can give it.

Oily and combination skin types will like it a lot better. It adds just that little extra touch of hydration your skin needs to stay soft and supple during the day/night.

Still, it’s more of a maintenance cream than anything else. You won’t see much improvement in the texture and brightness of your skin. It just keeps the status quo, so your skin doesn’t get worse.

I’m also not convinced that this alone can fight A.G.E.s. A diet mostly free of sugar (come on, you need a cheat day every now and then) will help more with this than any cream you can buy.

ishonest No.101 - Extract Dead Cells

No.101 - Extract Dead Cells

At least, it’s not comedogenic. I’ve been using it for weeks and not a single pimple has reared its ugly head.


A sleek jar with a black cap. I’m not a big fan of jars because they’re not hygienic. Thankfully, it comes with a spatula – problem solved.

Do You Need It?

No one needs a moisturiser this expensive. But if you’ve got combination skin and a fat wallet, you’ll like this.

Dupes & Alternatives


aqua / water / eau, propylene glycol, dimethicone, hydroxypropyl tetrahydropyrantriol, cyclohexasiloxane, isohexadecane, glycerin, synthetic wax, dimethicone/peg-10/15 crosspolymer, aluminum starch octenylsuccinate, ci 77163 / bismuth oxychloride, phenoxyethanol, magnesium sulfate, ethylhexyl hydroxystearate, salicyloyl phytosphingosine, acrylates copolymer, methylparaben, ethylparaben, disodium edta, vaccinium myrtillus extract / vaccinium myrtillus fruit extract, parfum / fragrance, butylphenyl methylpropional, coumarin

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