HYALURONIC ACID

By Claudia Shannon / Research Scientist / ishonest

This is a technical summary of published research on Hyaluronic Acid

  • For aging skin: A specific product (GliSODin Skin Nutrients Advanced Anti-Aging Formula, Isocell North America Inc.) containing krill oil, sea buckthorn berry oil, cacao bean extract, and hyaluronic acid, has been used daily for 90 days.
  • For osteoarthritis: A specific product (Oralvisc, Bioibrica) 80 mg has been used daily for 3 months.
  • For dry eye: Eye drops (Hyalistil, Hyalein, New Hyaluni, Hyaluni, Visaid) containing 0.1% to 0.3% hyaluronic acid have been used 3-8 times daily.
  • For swelling (inflammation) and sores inside the mouth (oral mucositis): Hyaluronic acid (Gelclair, Helsinn Healthcare SA) can be mixed with water and used as a mouth rinse.
  • For aging skin: Healthcare providers can inject a hyaluronic acid product (Juvderm Ultra Plus, Allergan) into skin wrinkles.
  • For osteoarthritis: Healthcare providers can inject hyaluronic acid into the joint.

Notable Sources

Baker, C. L., Jr. and Ferguson, C. M. Future treatment of osteoarthritis. Orthopedics 2005;28(2 Suppl): s227-s234.

de, Maio M. The minimal approach: an innovation in facial cosmetic procedures. Aesthetic Plast.Surg. 2004;28(5): 295-300.

Holmes and et al. Hyaluronic acid in human articular cartilage: Age-related changes in content and size. Biochem.J 1988;250: 435-441.

Kalman, D. S., Heimer, M., Valdeon, A., Schwartz, H., and Sheldon, E. Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal- Joint) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. Nutr J 2008;7: 3.

Laurent, T. C., Dahl, I. M., Dahl, L. B., Engstrom-Laurent, A., Eriksson, S., Fraser, J. R., Granath, K. A., Laurent, C., Laurent, U. B., Lilja, K., and . The catabolic fate of hyaluronic acid. Connect.Tissue Res 1986;15(1-2): 33-41.

Lupo, M. P. Hyaluronic acid fillers in facial rejuvenation. Semin.Cutan.Med Surg. 2006;25(3): 122-126.

Lupo, M. P., Smith, S. R., Thomas, J. A., Murphy, D. K., and Beddingfield, F. C., III. Effectiveness of Juvederm Ultra Plus dermal filler in the treatment of severe nasolabial folds. Plast.Reconstr.Surg. 2008;121(1): 289-297.

Paker, N., Tekdos, D., Kesiktas, N., and Soy, D. Comparison of the therapeutic efficacy of TENS versus intra-articular hyaluronic acid injection in patients with knee osteoarthritis: a prospective randomized study. Adv.Ther. 2006;23(2): 342-353.

Petrella, R. J. Hyaluronic acid for the treatment of knee osteoarthritis: long-term outcomes from a naturalistic primary care experience. Am J Phys.Med Rehabil. 2005;84(4): 278-283.

Rohrich, R. J., Ghavami, A., and Crosby, M. A. The role of hyaluronic acid fillers (Restylane) in facial cosmetic surgery: review and technical considerations. Plast.Reconstr.Surg. 2007;120(6 Suppl): 41S-54S.

Smith, K. C. Practical use of Juvederm: early experience. Plast.Reconstr.Surg. 2007;120(6 Suppl): 67S-73S.

Uthman, I., Raynauld, J. P., and Haraoui, B. Intra-articular therapy in osteoarthritis. Postgrad.Med J 2003;79(934): 449-453.

Abdulkareem AA, Al Marah ZA, Abdulbaqi HR, Alshaeli AJ, Milward MR. A randomized double-blind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilm- induced gingivitis. Int J Dent Hyg. 2020;18(3): 268-277.

Altman RD, Moskowitz R. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group. J Rheumatol 1998;25: 2203-12.

Altman RD. Intra-articular sodium hyaluronate in osteoarthritis of the knee. Semin Arthritis Rheum 2000;30(2 Suppl 1): 11-8.

Aragona P, Bentez-Del-Castillo JM, Coroneo MT, et al. Safety and efficacy of a preservative-free artificial tear containing carboxymethylcellulose and hyaluronic acid for dry eye disease: A randomized, controlled, multicenter 3- month study. Clin Ophthalmol. 2020;14: 2951-2963.

Bannuru RR, Osani MC, Vaysbrot EE, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis and cartilage. 2019;27: 1578-89.

Bardellini E, Amadori F, Schumacher RF, D'Ippolito C, Porta F, Majorana A. Efficacy of a solution composed by verbascoside, polyvinylpyrrolidone (PVP) and sodium hyaluronate in the treatment of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2016;38(7): 559-62.

Bergstrand S, Ingstad HK, Mystad A, Bjrnland T. Long-term effectiveness of arthrocentesis with and without hyaluronic acid injection for treatment of temporomandibular joint osteoarthritis. J Oral Sci. 2019;61(1): 82-88.

Chen CP, Hung W, Lin SH. Effectiveness of hyaluronic acid for treating diabetic foot: a systematic review and meta-analysis. Dermatol Ther. 2014;27(6): 331-6.

Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen 1999;7: 79-89.

Chen Z, Wang C, You D, Zhao S, Zhu Z, Xu M. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: A meta-analysis. Medicine (Baltimore). 2020;99(11): e19388.

Ciofalo A, de Vincentiis M, Zambetti G, et al. Olfactory dysfunction in acute rhinosinusitis: intranasal sodium hyaluronate as adjuvant treatment. Eur Arch Otorhinolaryngol. 2017;274(2): 803-808.

Concoff A, Sancheti P, Niazi F, Shaw P, Rosen J. The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2017;18(1): 542.

Delia P, Sansotta G, Pontoriero A, et al. Clinical Evaluation of Low-Molecular- Weight Hyaluronic Acid-Based Treatment on Onset of Acute Side Effects in Women Receiving Adjuvant Radiotherapy after Cervical Surgery: A Randomized Clinical Trial. Oncol Res Treat. 2019;42(4): 217-223.

Dougados M. Sodium hyaluronate therapy in osteoarthritis: arguments for a potential beneficial structural effect. Semin Arthritis Rheum 2000;30(2 Suppl 1): 19-25.

Duperre J, Grenier B, Lemire J, Mihalovits H, Sebag M, Lambert J. Effect of timolol vs. acetazolamide on sodium hyaluronate-induced rise in intraocular pressure after cataract surgery. Can J Ophthalmol 1994;29: 182-6.

Frizziero L, Govoni E, Bacchini P. Intra-articular hyaluronic acid in the treatment of osteoarthritis of the knee: clinical and morphological study. Clin Exp Rheumatol 1998;16: 441-9.

Gelclair Prescribing Information. Cell Pathways, Inc. Horsham, PA, 2002.

Goa KL, Benfield P. Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing. Drugs 1994;47: 536-66.

Goddard JC, Janssen DAW. Intravesical hyaluronic acid and chondroitin sulfate for recurrent urinary tract infections: systematic review and meta-analysis. Int Urogynecol J. 2018 Jul;29(7): 933-942. Epub 2017 Nov 27. Review.

Goldberg LD, Crysler C. A single center, pilot, double-blinded, randomized, comparative, prospective clinical study to evaluate improvements in the structure and function of facial skin with tazarotene 0.1% cream alone and in combination with GliSODin Skin Nutrients Advanced Anti-Aging Formula. Clin Cosmet Investig Dermatol. 2014;7: 139-44.

Gualdi G, Monari P, Cammalleri D, Pelizzari L, Calzavara-Pinton P. Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers. Wounds. 2019;31(3): 81-84.

He WW, Kuang MJ, Zhao J, et al. Efficacy and safety of intraarticular hyaluronic acid and corticosteroid for knee osteoarthritis: A meta-analysis. Int J Surg. 2017;39: 95-103.

Hermans J, Bierma-Zeinstra SMA, Bos PK, Niesten DD, Verhaar JAN, Reijman M. The effectiveness of high molecular weight hyaluronic acid for knee osteoarthritis in patients in the working age: a randomised controlled trial. BMC Musculoskelet Disord. 2019;20(1): 196.

Huang YC, Leong CP, Tso HH, et al. The long-term effects of hyaluronic acid on hemiplegic shoulder pain and injury in stroke patients: A randomized controlled study. Medicine (Baltimore). 2018;97(35): e12078.

Hyalgan Prescribing Information. Sanofi-Synthelabo, Inc. New York, NY, 2002.

Kavouni A, Stanec JJ. Human antihyaluronic acid antibodies. Dermatol Surg 2002;28: 359-60.

King SR, Hickerson WL, Proctor KG. Beneficial actions of exogenous hyaluronic acid on wound healing. Surgery 1991;109: 76-84.

Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Rheumatol. 2020 Feb;72(2): 220-33.

Kramer K, Senninger N, Herbst H, Probst W. Effective prevention of adhesions with hyaluronate. Arch Surg 2002;137: 278-82.

Lopez HL, Ziegenfuss TN, Park J. Evaluation of the Effects of BioCell Collagen, a Novel Cartilage Extract, on Connective Tissue Support and Functional Recovery From Exercise. Integr Med (Encinitas). 2015;14(3): 30-8.

Lpez-de la Rosa A, Pinto-Fraga J, Blzquez Arauzo F, Urbano Rodrguez R, Gonzlez-Garca MJ. Safety and efficacy of an artificial tear containing 0.3% hyaluronic acid in the management of moderate-to-severe dry eye disease. Eye Contact Lens. 2017;43(6): 383-388.

Luo P, Xiong Z, Sun W, Shi L, Gao F, Li Z. How to choose platelet-rich plasma or hyaluronic acid for the treatment of knee osteoarthritis in overweight or obese patients: A Meta-Analysis. Pain Res Manag. 2020;2020: 7587936.

Migliore A, Bizzi E, Herrero-Beaumont J, et al. The discrepancy between recommendations and clinical practice for viscosupplementation in osteoarthritis: mind the gap! Eur Rev Med Pharmacol Sci 2015;19(7): 1124-9.

Mozzanica F, Preti A, Gera R, et al. Double-blind, randomised controlled trial on the efficacy of saline nasal irrigation with sodium hyaluronate after endoscopic sinus surgery. J Laryngol Otol. 2019;133(4): 300-308.

Nelson FR, Zvirbulis RA, Zonca B, et al. The effects of an oral preparation containing hyaluronic acid (Oralvisc) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. Rheumatol Int. 2015;35(1): 43-52.

New Product: Gelclair concentrated oral gel. Pharmacist's Letter/Prescriber's Letter 2002;18(7): 180711.

Origoni M, Cimmino C, Carminati G, et al. Postmenopausal vulvovaginal atrophy (VVA) is positively improved by topical hyaluronic acid application. A prospective, observational study. Eur Rev Med Pharmacol Sci. 2016;20(20): 4190-4195.

Palmieri B, Merighi A, Corbascio D, Rottigni V, Fistetto G, Esposito A. Fixed combination of hyaluronic acid and chondroitin-sulphate oral formulation in a randomized double blind, placebo controlled study for the treatment of symptoms in patients with non-erosive gastroesophageal reflux. Eur Rev Med Pharmacol Sci 2013;17(24): 3272-8.

Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2): 66-72.

Percival SP. Complications from use of sodium hyaluronate (Healonid) in anterior segment surgery. Br J Ophthalmol 1982;66: 714-6.

Percival SP. Sodium hyaluronate in perspective: experiences from a four-year clinical trial. Trans Ophthalmol Soc U K 1985;104: 616-20.

Petrella RJ, DiSilvestro MD, Hildebrand C. Effects of hyaluronate sodium on pain and physical functioning in osteoarthritis of the knee: a randomized, double- blind, placebo-controlled clinical trial. Arch Intern Med 2002;162: 292-8.

Pinto-Fraga J, Lpez-de la Rosa A, Blzquez Arauzo F, Urbano Rodrguez R, Gonzlez-Garca MJ. Efficacy and safety of 0.2% hyaluronic acid in the management of dry eye disease. Eye Contact Lens. 2017;43(1): 57-63.

Rolando M, Valente C. Establishing the tolerability and performance of tamarind seed polysaccharide (TSP) in treating dry eye syndrome: results of a clinical study. BMC Ophthalmol 2007;7: 5.

Ruggiero T, Pol R, Camisassa D, et al. Use of sodium hyaluronate and synthetic amino acid precursors of collagen for the symptomatic treatment of mucositis in patients undergoing haematopoietic stem cell transplants. J Biol Regul Homeost Agents. 2016;30(3): 889-894.

Rutjes AW, Juni P, da Costa BR, Trelle S, Nuesch E, Reichenbach S. Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. Ann Intern Med. 2012 Augh 7;157(3): 180-91.

Ruusuvaara P, Pajari S, Setala K. Effect of sodium hyaluronate on immediate postoperative intraocular pressure after extracapsular cataract extraction and IOL implantation. Acta Ophthalmol (Copenh) 1990;68: 721-7.

Savarino V, Pace F2, Scarpignato C; Esoxx Study Group. Randomised clinical trial: mucosal protection combined with acid suppression in the treatment of non-erosive reflux disease - efficacy of Esoxx, a hyaluronic acid-chondroitin sulphate based bioadhesive formulation. Aliment Pharmacol Ther. 2017;45(5): 631-642.

Savietto E, Marioni G, Maculan P, et al. Effectiveness of micronized nasal irrigations with hyaluronic acid/isotonic saline solution in non-polipoid chronic rhinosinusitis: A prospective, randomized, double-blind, controlled study. Am J Otolaryngol. 2020;41(4): 102502. View abstract.

Schauss AG, Stenehjem J, Park J, Endres JR, Clewell A. Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, double- blind, placebo-controlled trial. J Agric Food Chem. 2012;60(16): 4096-4101. View abstract.

Schwartz SR, Park J. Ingestion of BioCell Collagen, a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs. Clin Interv Aging. 2012;7: 267-273. View abstract.

Soderberg O, Hellstrom S. Consequences of using hyaluronan-coated tympanostomy tubes. Acta Otolaryngol Suppl 1987;442: 50-3. View abstract.

Stamper RL, DiLoreto D, Schacknow P. Effect of intraocular aspiration of sodium hyaluronate on postoperative intraocular pressure. Ophthalmic Surg. 1990;21: 486-91. View abstract.

Synvisc Prescribing Information. Wyeth-Ayerst Pharmaceuticals, Philadelphia, PA, 2000.

Tang X, Zhou ZK, Shen B, Kang PD, Pei FX, Li J. Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee. Int J Rheum Dis. 2019;22(3): 392-398. View abstract.

Torella M, Del Deo F, Grimaldi A, et al. Efficacy of an orally administered combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin for the prevention of recurrent urinary tract infections in postmenopausal women. Eur J Obstet Gynecol Reprod Biol. 2016;207: 125-128. View abstract.

Voigt J., Driver VR. Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: a systematic review and meta-analysis of randomized controlled trials. Wound Repair Regen. 2012;20(3): 317-31. View abstract.

von Tirpitz C, Klaus J, Bruckel J, et al. Increase of bone mineral density with sodium fluoride in patients with Crohn's disease. Eur J Gastroenterol Hepatol 2000;12: 19-24.. View abstract.

Yang Z, Li M, Xiao L, Yi Z, Zhao M, Ma S. Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis. Braz J Med Biol Res. 2020;53(8): e9886. View abstract.

Ye Y, Zhou X, Mao S, Zhang J, Lin B. Platelet rich plasma versus hyaluronic acid in patients with hip osteoarthritis: A meta-analysis of randomized controlled trials. Int J Surg. 2018;53: 279-287. View abstract.


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