Cholinergic Urticaria

Curated by Claudia Shannon / Research Scientist / ishonest

What Is Cholinergic Urticaria?

It's not clear what causes this condition. Some evidence suggests it may be due to the nervous system or from an allergic response to sweat. You may be more likely to get these hives if you have eczema, asthma, or other allergies like hay fever, or if you get hives for other reasons, such as from certain foods or medications, pressure on your skin, or cold weather. Anyone can get cholinergic urticaria.

Some people with CU have only a mild case of the condition; but others can get a serious or life-threatening version of the disease. Signs and symptoms of a serious case of CU include:

  • Hives all over your body (generalized urticaria)
  • Swelling in the deeper layers of the skin (angioedema) often around the face and lips. If swelling causes your throat or tongue to block your airway, this can be life-threatening.
  • Bronchospasm. Your airways go into spasm and contract abnormally, making it difficult to breathe. You can also have wheezing or coughing.
  • Low blood pressure (hypotension). Very low blood pressure can be life- threatening.

Cholinergic Urticaria Symptoms

These hives are itchy, tingly, and warm. They're usually small (1-3 millimeter) red bumps with flares or circles around them called wheals.

You can get them anywhere on your body, but most of the time they show up on your chest, face, upper back, and arms. Sometimes, the bumps are close together. Your skin can look swollen and blotchy, or you may just look flushed.

CU hives pop up within 6 minutes of contact with a trigger. They last about 30 minutes to an hour or two before they fade away. It's not common, but you also may have one or more of these along with hives:

  • Diarrhea
  • Extra saliva in your mouth
  • Headache
  • Lightheadedness
  • Low blood pressure
  • Rapid heartbeat
  • Shortness of breath
  • Stomach cramps
  • Wheezing

Cholinergic Urticaria Causes and Risk Factors

CU is caused by nerve fibers in your sweat glands. Your skin reacts to the heat and sweat when your body temperature goes up. You may get these hives when you:

  • Take a hot shower or bath
  • Work up a sweat from exercise
  • Are in a hot climate
  • Wear a tight, clingy bandage Get nervous, have anxiety, or start to sweat
  • Eat hot or spicy foods
  • Are upset or angry

Cholinergic Urticaria Diagnosis

If you notice that your skin gets itchy, red, and blotchy when you're hot or you're a few minutes into a workout, see your doctor. A dermatologist (skin specialist) or allergist can also diagnose CU. In order to diagnose it:

Your doctor will ask you what your hives look like when you get them and how long they last to rule out other causes, such as foods you eat. They may ask you to run or ride a stationary bike for about 15 minutes to see whether you break out as you sweat. They may give you a shot of methacholine, a medicine that shrinks your airways, to make the bumps show up.

Cholinergic Urticaria Treatment

If you live in a hot climate or like to exercise, it can be hard to stay away from the heat that causes these hives. These allergies/antihistamines, used to treat allergies, may help control them:

  • Cetirizine (Zyrtec)
  • Diphenhydramine (Benadryl)
  • Hydroxyzine (Atarax, Vistaril)
  • Fexofenadine (Allegra)
  • Loratadine (Alavert, Claritin)

Cholinergic Urticaria Prevention

Stop or slow down your workouts if you break out in hives. If some types of exercise make you break out more often, try other activities instead. Cool your hot skin to prevent or ease hives:

  • Try a cool shower, press a cloth soaked in cool water to your skin, or stand in front of a fan. Wear loose clothes.
  • Keep your home and bedroom at a cool temperature. If stress causes your hives, try to avoid situations that upset you. Find ways to calm down and manage it.

Read more on: urticaria, cholinergic urticaria

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