Niacinamide

Curated by Claudia Shannon / Research Scientist / ishonest

This is a technical paper for research purposes only

    • General: Some dietary supplement products might not list niacinamide separately on the label. Instead, it might be listed under niacin. Niacin is measured in niacin equivalents (NE). A dose of 1 mg of niacinamide is the same as 1 mg NE. The daily recommended dietary allowances (RDAs) for niacinamide in adults are 16 mg NE for men, 14 mg NE for women, 18 mg NE for pregnant women, and 17 mg NE for lactating women.
    • For acne: Tablets containing 750 mg of niacinamide, 25 mg of zinc, 1.5 mg of copper, and 500 mcg of folic acid (Nicomide) once or twice daily have been used. Also, 1-4 tablets containing niacinamide, azelaic acid, zinc, vitamin B6, copper, and folic acid (NicAzel, Elorac Inc., Vernon Hills, IL) have been taken daily.
    • For vitamin B3 deficiency symptoms such as pellagra: 300-500 mg per day of niacinamide is given in divided doses.
For diabetes
    : Niacinamide 1.2 grams/m2 (body surface area) or 25-50 mg/kg is used daily for slowing progression of type 1 diabetes. Also, 0.5 grams of niacinamide three times daily is used to slow the progression of type 2 diabetes.
  • For high levels of phosphate in the blood (hyperphosphatemia): Niacinamide from 500 mg up to 1.75 grams daily in divided doses is used for 8-12 weeks.
  • For cancer of the larynx: 60 mg/kg of niacinamide is given 1-1.5 hours before inhaling carbogen (2% carbon dioxide and 98% oxygen) before and during radiotherapy.
  • For skin cancers other than melanoma: 500 mg of niacinamide once or twice daily for 4-12 months.
  • For treating osteoarthritis: 3 grams of niacinamide per day in divided doses for 12 weeks.
  • Acne: A gel containing 4% niacinamide twice daily.
  • General: The daily recommended dietary allowances (RDAs) for niacinamide in children are 2 mg for infants 0-6 months of age, 4 mg NE for infants 7-12 months of age, 6 mg NE for children 1-3 years of age, 8 mg NE for children 4-8 years of age, 12 mg NE for children 9-13 years of age, 16 mg NE for men 14-18 years of age, and 14 mg NE for women 14-18 years of age.
  • For acne: In children at least 12 years of age, 1-4 tablets containing niacinamide, azelaic acid, zinc, vitamin B6, copper, and folic acid (NicAzel, Elorac Inc., Vernon Hills, IL) are taken daily.
  • For pellagra: 100-300 mg of niacinamide is given daily in divided doses.
  • For type 1 diabetes: 1.2 grams/m2 (body surface area) or 25-50 mg/kg of niacinamide is used daily for slowing progression of or preventing type 1 diabetes.

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